Traditional dosimetry methods are based on effective dose calculations, which do not fully take into account individual factors such as age, diet and health. These limitations increase uncertainty in dose estimation, particularly for vulnerable groups such as children and pregnant women. Biokinetic models play a crucial role in internal dosimetry by predicting the behaviour of radionuclides in the body. However, currently available models, including those recommended by the International Commission on Radiological Protection (ICRP), provide generalized dose assessments that may not reflect individual variability, potentially affecting risk assessment and emergency response strategies.

To address these limitations, researchers of the HUN-REN Centre for Energy Research have initiated the development of a new biokinetic model for the thyroid, that takes into account dietary habits and age-related physiological changes. This approach aims to improve the accuracy of dose estimation by reflecting variations in iodine metabolism. As part of this research, computational modeling techniques have been implemented and preliminary evaluations against reference models were carried out. On this basis, the aim of this proposal to extend the method to other organs, such as the lungs, and to further refine the model to improve its predictive capabilities.

The PhD student will contribute to this research by:

• Refining and validating of the thyroid biokinetic model using computational simulations and experimental data.
• Extending the modeling approach to other critical organs, such as the lungs.
• Taking measurements on a selected group of people to compare model predictions with real data.
• Evaluating the uncertainty associated with dose estimations and its impact on risk assessment.
• Comparing the developed models with existing ICRP reference models.
• Investigating opportunities for optimizing protective actions based on individualized dose assessments.

The PhD candidate will have the opportunity to participate in international cooperations. Professional support will be provided to the PhD candidate by the Radiation Protection Department of the HUN-REN Centre for Energy Research.